The 26-episode TV series, Zone of the Enders: Dolores,i is the second anime work of the Zone of the Enders video game series. Like 2173 Testament / Fist of Mars, Dolores,i takes place in the same universe as Zone of the Enders and features a new story with original characters.

Z.O.E: Dolores,i adds a comical and adventurous theme to the world of Zone of the Enders, depicting the events that occur as the origin of a strange Orbital Frame are discovered.